"Unprecedented global forces are shaping the health of adolescents everywhere, requiring new responses, different actors and wider alliances. The 12th IAAH World Congress on Adolescent Health is a unique opportunity to explore the challenge of global change. Whether you are a clinician, policy maker, researcher or trainee, this meeting will promote your engagement with like-minded colleagues from across the world who work in health services, schools and communities, academia, government ministries, global agencies and NGOs. The World Congress will challenge you to think and respond differently as clinical and public health challenges are debated, alternative policies are explored and the latest adolescent health research is shared. Multidisciplinary trainees are especially welcome. Please join us in November 2021 at the 12th IAAH World Congress at the Digital Convention Center of our organizing partner, Grupo Milenium, where I trust you will also find time to enjoy the gastronomic highlights and its wonders."